PAC

• Target:

  Estrogen Receptor/ERR|||PROTAC-Linker Conjugates for PAC

• Related Pathways:

  Endocrinology/Hormones|||Antibody-drug Conjugate/ADC Related

• Bioactivity:

  PAC is a chemical conjugate consisting of an ADCs linker and PROTACs linked to an antibody. When PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ER?) in comparison to PROTAC alone.

• Smiles:

  CCC (=C (c1ccc (OCCN (C) C (=O) COCCOCCNC (=O) c2ccc (cc2) C (=O) N2[C@@H] (C) [C@H] (NC (=O) [C@H] (C) NC) C (=O) N (Cc3c (OC) ccc4ccccc34) c3ccc (cc23) C#N) cc1) c1ccc (OCc2ccc (NC (=O) [C@H] (CCCNC (N) =O) NC (=O) [C@@H] (NC (=O) CCCCCN3C (=O) C=CC3=O) C (C) C) cc2) cc1) c1ccccc1 |w:3.3, c:112|

• Molecular Formula:

  C94H107N13O16

• Molecular Weight:

  1674.965

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2158322-33-7