Pomalidomide-PEG1-C2-N3

• Target :

  Others|||E3 Ligase Ligand-Linker Conjugate

• Related Pathways :

  Others|||PROTAC

• Bioactivity :

  Pomalidomide-PEG1-C2-N3, a conjugate of an E3 ligase ligand-linker, incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, commonly used in PROTAC technology. This compound enables the design of the selective CDK6 PROTAC degrader CP-10, which effectively induces CDK6 degradation with a DC50 value of 2.1 nM[1].

• Smiles :

  [N-]=[N+]=NCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

• Molecular Formula :

  C17H18N6O5

• Molecular Weight :

  386.36

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2271036-44-1