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Pomalidomide-PEG1-C2-N3

CAT: 0931-T17904Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T17904Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2271036-44-1
Target
Others, E3 Ligase Ligand-Linker Conjugate
Related Pathways
Others, PROTAC
Bioactivity
Pomalidomide-PEG1-C2-N3, a conjugate of an E3 ligase ligand-linker, incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, commonly used in PROTAC technology. This compound enables the design of the selective CDK6 PROTAC degrader CP-10, which effectively induces CDK6 degradation with a DC50 value of 2.1 nM[1].
Smiles
[N-]=[N+]=NCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Molecular Formula
C17H18N6O5
Molecular Weight
386.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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