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β-Naphthoflavone-CH2-OH

CAT: 0931-T17363-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T17363-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others, E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC, Others
Bioactivity
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) . These chimeric molecules recruit the AhR E3 ligase complex by incorporating AhR ligands. By inducing ubiquitination-mediated degradation, PROTACs effectively target and degrade cancer-promoting proteins [1].
Smiles
O=C1C=C(C2=CC=C(CO)C=C2)OC3=C1C4=CC=CC=C4C=C3
Molecular Formula
C20H14O3
Molecular Weight
302.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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