Tefinostat

• Target :

  Apoptosis|||HDAC

• Related Pathways :

  Chromatin/Epigenetic|||Apoptosis|||DNA Damage/DNA Repair

• Purity :

  0.9983

• Bioactivity :

  Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor that is cleaved to the active acid CHR-2847 by intracellular esterase human carboxylesterase-1 (hCE-1) . Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.

• Smiles :

  ONC(=O)CCCCCCC(=O)Nc1ccc(CN[C@H](C(=O)OC2CCCC2)c2ccccc2)cc1

• Molecular Formula :

  C28H37N3O5

• Molecular Weight :

  495.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  914382-60-8