Products for Research Use Only
RegisterLogin

Tefinostat

CAT: 0804-HY-106409-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-106409-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1) . Tefinostat can be used for the research of leukaemias[1].
CAS Number
914382-60-8
Product Name Alternative
CHR-2845
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tefinostat.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC1CCCC1)[C@H](C2=CC=CC=C2)NCC3=CC=C(NC(CCCCCCC(NO)=O)=O)C=C3
Molecular Formula
C28H37N3O5
Molecular Weight
495.61
References & Citations
[1]Zabkiewicz J, et al. The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Oncotarget. 2016 Mar 29;7 (13) :16650-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
HDAC

Alternative Products

CatalogName
BA3079-10Tefinostat
A20258-100Tefinostat 100mg
A20258-50Tefinostat 50mg
A20258-5Tefinostat 5mg
A20258-25Tefinostat 25mg
A20258-10Tefinostat 10mg
A20258-1Tefinostat 1mg
E1554-01Tefinostat (CHR-2845)
A20258-10mM-DTefinostat 10mM * 1mL in DMSO

Popular Products