TCS 21311

• Target:

  JAK|||GSK-3|||PKC

• Related Pathways:

  PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Cytoskeletal Signaling|||Chromatin/Epigenetic|||Angiogenesis|||Stem Cells

• Purity:

  0.9939

• Bioactivity:

  TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM) . TCS 21311 inhibits PKC?, PKC?, and GSK3? (IC50s: 13, 68, and 3 nM, respectively) . It displays >100-fold selectivity over JAK1, JAK2, and TYK2.

• Smiles:

  CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F

• Molecular Formula:

  C27H25F3N4O4

• Molecular Weight:

  526.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1260181-14-3