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TCS 21311

CAT: 0931-T17019-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T17019-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1260181-14-3
Target
JAK, GSK-3, PKC
Related Pathways
PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Cytoskeletal Signaling, Chromatin/Epigenetic, Angiogenesis, Stem Cells
Purity
0.9939
Bioactivity
TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM) . TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively) . It displays >100-fold selectivity over JAK1, JAK2, and TYK2.
Smiles
CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F
Molecular Formula
C27H25F3N4O4
Molecular Weight
526.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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