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TC13172

CAT: 0931-T17010Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T17010Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2093393-05-4
Target
MLK
Related Pathways
MAPK
Bioactivity
TC13172 is a potent and covalent inhibitor that specifically targets the mixed lineage kinase domain-like protein (MLKL), exhibiting significant selectivity for MLKL over the closely related receptor-interacting serine/threonine kinase 1 (RIPK1) and RIPK3 at a concentration of 10 μM.TC13172 effectively inhibits necroptosis induced by the TSZ combination (TNF-α, a Smac mimetic, and Z-VAD-FMK) in HT-29 cells with a EC50 of 2 nM and, at 100 nM, blocks TSZ-induced oligomerization and plasma membrane translocation of MLKL.
Smiles
O=C1C2=C(N=C(N2C)S(=O)(=O)C)N(C(=O)N1C)CC#CC=3C=CC=C(O)C3
Molecular Formula
C17H16N4O5S
Molecular Weight
388.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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BA6507-5TC13172
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GTR19237518-01TC13172-NH-COOH
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