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SU16f

CAT: 0931-T16947-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T16947-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
251356-45-3
Target
PDGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9838
Bioactivity
SU16f (3-substituted indolin-2-one 16f) is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively) . Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration.
Smiles
C(=C1C=2C(=CC(=CC2)C3=CC=CC=C3)NC1=O)C4=C(C)C(CCC(O)=O)=C(C)N4
Molecular Formula
C24H22N2O3
Molecular Weight
386.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

3-[2,4-dimethyl-5-[(Z)-(2-oxo-6-phenyl-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
CAS Number251356-45-3
PubChem CID5329150
IUPAC Name3-[2,4-dimethyl-5-[(Z)-(2-oxo-6-phenyl-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
Molecular FormulaC24H22N2O3
Molecular Weight386.4
XLogP3.9
Topological Polar Surface Area82.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count29
Formal Charge0
Complexity655
SMILES
CC1=C(NC(=C1CCC(=O)O)C)/C=C\2/C3=C(C=C(C=C3)C4=CC=CC=C4)NC2=O
InChI
InChI=1S/C24H22N2O3/c1-14-18(10-11-23(27)28)15(2)25-21(14)13-20-19-9-8-17(12-22(19)26-24(20)29)16-6-4-3-5-7-16/h3-9,12-13,25H,10-11H2,1-2H3,(H,26,29)(H,27,28)/b20-13-
InChIKey
APYYTEJNOZQZNA-MOSHPQCFSA-N
Chemical Structure
2D Structure
2D structure of 3-[2,4-dimethyl-5-[(Z)-(2-oxo-6-phenyl-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
CAS: 251356-45-3
CID: 5329150
Formula: C24H22N2O3
MW: 386.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight386.4
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass386.16304257
Monoisotopic Mass386.16304257
Topological Polar Surface Area82.2 Ų
Heavy Atom Count29
Formal Charge0
Complexity655
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3615440-01SU16f

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