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QC6352

CAT: 0931-T16700-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T16700-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1851373-36-8
Target
Histone Demethylase
Related Pathways
Chromatin/Epigenetic
Bioactivity
QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM) .
Smiles
CN(c1ccccc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1
Molecular Formula
C24H25N3O2
Molecular Weight
387.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

QC6352

QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations.

CAS Number1851373-36-8
PubChem CID118598059
IUPAC Name3-[[(1R)-6-(N-methylanilino)-1,2,3,4-tetrahydronaphthalen-1-yl]methylamino]pyridine-4-carboxylic acid
Molecular FormulaC24H25N3O2
Molecular Weight387.5
XLogP5.3
Topological Polar Surface Area65.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity536
SMILES
CN(C1=CC=CC=C1)C2=CC3=C(C=C2)[C@@H](CCC3)CNC4=C(C=CN=C4)C(=O)O
InChI
InChI=1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m0/s1
InChIKey
XSMABFRQESMONQ-SFHVURJKSA-N
Chemical Structure
2D Structure
2D structure of QC6352
CAS: 1851373-36-8
CID: 118598059
Formula: C24H25N3O2
MW: 387.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight387.5
XLogP35.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass387.19467705
Monoisotopic Mass387.19467705
Topological Polar Surface Area65.5 Ų
Heavy Atom Count29
Formal Charge0
Complexity536
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-104048-01QC6352
A19477-25QC6352 25mg
A19477-10QC6352 10mg
A19477-100QC6352 100mg
A19477-5QC6352 5mg
A19477-1QC6352 1mg
A19477-50QC6352 50mg
A19477-10mM-DQC6352 10mM * 1mL in DMSO

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