Products for Research Use Only
RegisterLogin

QC6352

CAT: 0804-HY-104048-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-104048-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC50s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC50 of 750 nM (KDM5B) [1][2].
CAS Number
1851373-36-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/QC6352.html
Purity
99.13
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC[C@@H]2CCCC3=C2C=CC(N(C)C4=CC=CC=C4)=C3)C=NC=C1)O
Molecular Formula
C24H25N3O2
Molecular Weight
387.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen YK, et al. Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett. 2017 Jul 27;8 (8) :869-874.|[2]Metzger E, et al. KDM4 inhibition targets breast cancer stem-like cells. Cancer Res. 2017 Sep 7. pii: canres.1754.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM4; KDM5

Alternative Products

CatalogName
BA4780-5.1QC6352
A19477-25QC6352 25mg
A19477-10QC6352 10mg
A19477-5QC6352 5mg
A19477-1QC6352 1mg
A19477-100QC6352 100mg
A19477-50QC6352 50mg
A19477-10mM-DQC6352 10mM * 1mL in DMSO

Popular Products