PAT-048

• Target :

  PDE

• Related Pathways :

  Metabolism

• Bioactivity :

  PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in the lung fibrosis model. PAT-048 has an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma.

• Smiles :

  CC=1N(C=2C(C1SC3=C(F)C(C(O)=O)=CC=C3)=CC=C(Cl)C2F)C4=CN(CCC)N=C4

• Molecular Formula :

  C22H18ClF2N3O2S

• Molecular Weight :

  461.91

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1359983-15-5