PAT-347

• Target :

  Others|||PDE

• Related Pathways :

  Metabolism|||Others

• Bioactivity :

  PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signaling pathway is implicated in cell survival, migration, and proliferation; thus, the inhibition of ATX is a recognized therapeutic target for a number of diseases including fibrotic diseases, cancer, and inflammation, among others.

• Smiles :

  C(CN1C=2C(C(SC3=C(F)C(C(O)=O)=CC=C3)=C1C)=CC=C(Cl)C2F)(=O)N4CC5(C=6C4=CC=CC6)CC5

• Molecular Formula :

  C28H21ClF2N2O3S

• Molecular Weight :

  538.99

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1689554-51-5