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NU6140

CAT: 0931-T16359-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T16359-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
444723-13-1
Target
CDK, Aurora Kinase
Related Pathways
Chromatin/Epigenetic, Cell Cycle/Checkpoint
Purity
0.9833
Bioactivity
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM) . It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively) . It also enhances the apoptotic effect and has anti-cancer activity.
Smiles
CCN(CC)C(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3[nH]cnc3n2)cc1
Molecular Formula
C23H30N6O2
Molecular Weight
422.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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