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Hydralazine hydrochloride

CAT: 0931-T1613-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0931-T1613-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
304-20-1
Target
HIF/HIF Prolyl-Hydroxylase, MAO, Apoptosis, Bcl-2 Family, Caspase
Related Pathways
Proteases/Proteasome, Chromatin/Epigenetic, Apoptosis, Neuroscience, Metabolism
Purity
0.9986
Bioactivity
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.
Smiles
NNC1=NN=CC2=CC=CC=C12
Molecular Formula
C8H9ClN4
Molecular Weight
196.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Hydralazine Hydrochloride

Hydralazine hydrochloride is the hydrochloride salt of hydralazine; a direct-acting vasodilator that is used as an antihypertensive agent. It has a role as a vasodilator agent and an antihypertensive agent. It contains a hydralazine.

CAS Number304-20-1
PubChem CID9351
IUPAC Namephthalazin-1-ylhydrazine;hydrochloride
Molecular FormulaC8H9ClN4
Molecular Weight196.64
Topological Polar Surface Area63.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count13
Formal Charge0
Complexity150
SMILES
C1=CC=C2C(=C1)C=NN=C2NN.Cl
InChI
InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
InChIKey
ZUXNZUWOTSUBMN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hydralazine Hydrochloride
CAS: 304-20-1
CID: 9351
Formula: C8H9ClN4
MW: 196.64
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight196.64
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass196.0515740
Monoisotopic Mass196.0515740
Topological Polar Surface Area63.8 Ų
Heavy Atom Count13
Formal Charge0
Complexity150
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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