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MLi-2

CAT: 0931-T16115-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T16115-01Size:1 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1627091-47-7
Target
LRRK2
Related Pathways
Autophagy
Purity
0.9933
Bioactivity
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM) .
Smiles
C[C@H]1CN(C[C@@H](C)O1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Molecular Formula
C21H25N5O2
Molecular Weight
379.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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