LY 345899

• Target :

  DHFR|||Dehydrogenase

• Related Pathways :

  Metabolism|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

• Purity :

  0.997

• Bioactivity :

  LY 345899 is a folate analog that inhibits methylenetetrahydrofolate dehydrogenase and MTHFD2, with IC50 values of 96 nM and 663 nM, respectively, and a Ki of 18 nM for MTHFD1.

• Smiles :

  Nc1nc2NCC3CN(C(=O)N3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

• Molecular Formula :

  C20H21N7O7

• Molecular Weight :

  471.42

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  10538-99-5