Leptomycin B

• Target:

  Antifungal|||CRM1|||Antibiotic

• Related Pathways:

  Membrane transporter/Ion channel|||Microbiology/Virology

• Purity:

  0.9971

• Bioactivity:

  Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue.

• Smiles:

  CC\C(\C=C\[C@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O

• Molecular Formula:

  C33H48O6

• Molecular Weight:

  540.73

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  87081-35-4