Leptomycin B

• Target:

  Antifungal|||CRM1|||Antibiotic

• Related Pathways:

  Membrane transporter/Ion channel|||Microbiology/Virology

• Purity:

  0.9971

• Bioactivity:

  Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue.

• Smiles:

  CC\C (\C=C\[C@H]1OC (=O) C=C[C@@H]1C) =C\[C@H] (C) C\C=C\C (\C) =C\[C@@H] (C) C (=O) [C@@H] (C) [C@H] (O) [C@@H] (C) C\C (C) =C\C (O) =O

• Molecular Formula:

  C33H48O6

• Molecular Weight:

  540.73

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  87081-35-4