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GN44028

CAT: 0931-T15396-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T15396-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1421448-26-1
Target
HIF/HIF Prolyl-Hydroxylase, HIF
Related Pathways
Metabolism, Angiogenesis, Chromatin/Epigenetic
Purity
0.9952
Bioactivity
GN44028 (N- (2,3-Dihydro-1,4-benzodioxin-6-yl) -1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF) -1 (IC50: 14 nM) . GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization.
Smiles
C1c2ccccc2-c2[nH]nc(Nc3ccc4OCCOc4c3)c12
Molecular Formula
C18H15N3O2
Molecular Weight
305.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
CAS Number1421448-26-1
PubChem CID71625259
IUPAC NameN-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[2,1-d]pyrazol-3-amine
Molecular FormulaC18H15N3O2
Molecular Weight305.3
XLogP3.5
Topological Polar Surface Area59.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity434
SMILES
C1COC2=C(O1)C=CC(=C2)NC3=NNC4=C3CC5=CC=CC=C54
InChI
InChI=1S/C18H15N3O2/c1-2-4-13-11(3-1)9-14-17(13)20-21-18(14)19-12-5-6-15-16(10-12)23-8-7-22-15/h1-6,10H,7-9H2,(H2,19,20,21)
InChIKey
CGZKSZVSWAAUHE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
CAS: 1421448-26-1
CID: 71625259
Formula: C18H15N3O2
MW: 305.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight305.3
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass305.116426730
Monoisotopic Mass305.116426730
Topological Polar Surface Area59.2 Ų
Heavy Atom Count23
Formal Charge0
Complexity434
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
E7505-1mgGN44028
A19693-200GN44028 200mg
A19693-1GN44028 1mg
A19693-10GN44028 10mg
A19693-5GN44028 5mg
A19693-100GN44028 100mg
A19693-50GN44028 50mg
A19693-25GN44028 25mg
A19693-10mM-DGN44028 10mM * 1mL in DMSO
bs-60325C-01GN44028 --- HIF-1α Inhibitor

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