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Flindokalner

CAT: 0931-T15286-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T15286-07Size:100 mg
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CAS Number
187523-35-9
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9996
Bioactivity
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. It is also a positive modulator of large conductance calcium-activated K channels (BKca) and displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) . Additionally, Flindokalner acts as a negative modulator of GABAA receptors and demonstrates anxiolytic efficacy in vivo.
Smiles
COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
Molecular Formula
C16H10ClF4NO2
Molecular Weight
359.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Bms 204352

a calcium-sensitive opener of maxi-K potassium channels; structure in first source

CAS Number187523-35-9
PubChem CID214350
IUPAC Name(3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2-one
Molecular FormulaC16H10ClF4NO2
Molecular Weight359.70
XLogP4.2
Topological Polar Surface Area38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity503
SMILES
COC1=C(C=C(C=C1)Cl)[C@]2(C3=C(C=C(C=C3)C(F)(F)F)NC2=O)F
InChI
InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChIKey
ULYONBAOIMCNEH-HNNXBMFYSA-N
Chemical Structure
2D Structure
2D structure of Bms 204352
CAS: 187523-35-9
CID: 214350
Formula: C16H10ClF4NO2
MW: 359.70
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight359.70
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass359.0336189
Monoisotopic Mass359.0336189
Topological Polar Surface Area38.3 Ų
Heavy Atom Count24
Formal Charge0
Complexity503
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
525063Flindokalner
HY-108584R-01Flindokalner (Standard)

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