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Delgocitinib

CAT: 0931-T15096-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T15096-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1263774-59-9
Target
JAK, Tyrosine Kinases
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling, Stem Cells
Purity
0.9995
Bioactivity
Delgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune diseases through JAK-dependent cytokines and can effectively suppress multiple cytokine signaling while inhibiting itching caused by cytokines. It is widely used to treat various inflammatory diseases, including autoimmune diseases and hypersensitivity reactions.
Smiles
C[C@H]1CN(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12
Molecular Formula
C16H18N6O
Molecular Weight
310.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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