Methotrexate

• Target:

  ADC Cytotoxin|||Dehydrogenase|||Apoptosis|||DNA/RNA Synthesis|||Antifolate

• Related Pathways:

  Antibody-drug Conjugate/ADC Related|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Metabolism|||Apoptosis

• Purity:

  0.9991

• Bioactivity:

  Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.

• Smiles:

  NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

• Molecular Formula:

  C20H22N8O5

• Molecular Weight:

  454.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  59-05-2