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BNC375

CAT: 0931-T14695-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T14695-01Size:1 mL - 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1557240-80-8
Target
AChR, Others
Related Pathways
Neuroscience, Others
Bioactivity
BNC375 is a α7 nAChRs type I positive allosteric modulator (EC50: 1.9 μM) .
Smiles
COc1ccc(Cl)cc1NC[C@@H]1[C@@H](c2ccc(cc2)S(N)(=O)=O)C1(C)C
Molecular Formula
C19H23ClN2O3S
Molecular Weight
394.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Bnc375

alpha 7 nicotinic acetylcholine receptor-positive allosteric modulator

CAS Number1557240-80-8
PubChem CID118160666
IUPAC Name4-[(1R,3R)-3-[(5-chloro-2-methoxyanilino)methyl]-2,2-dimethylcyclopropyl]benzenesulfonamide
Molecular FormulaC19H23ClN2O3S
Molecular Weight394.9
XLogP4
Topological Polar Surface Area89.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity584
SMILES
CC1([C@@H]([C@H]1C2=CC=C(C=C2)S(=O)(=O)N)CNC3=C(C=CC(=C3)Cl)OC)C
InChI
InChI=1S/C19H23ClN2O3S/c1-19(2)15(11-22-16-10-13(20)6-9-17(16)25-3)18(19)12-4-7-14(8-5-12)26(21,23)24/h4-10,15,18,22H,11H2,1-3H3,(H2,21,23,24)/t15-,18-/m1/s1
InChIKey
LWWDCTBUJUEFDE-CRAIPNDOSA-N
Chemical Structure
2D Structure
2D structure of Bnc375
CAS: 1557240-80-8
CID: 118160666
Formula: C19H23ClN2O3S
MW: 394.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight394.9
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass394.1117915
Monoisotopic Mass394.1117915
Topological Polar Surface Area89.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity584
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T14694-01BNC105

Alternative Products

CatalogName
BA6817-10BNC375
A18503-5BNC375 5mg
A18503-10BNC375 10mg
A18503-100BNC375 100mg
A18503-50BNC375 50mg
A18503-25BNC375 25mg
A18503-10mM-DBNC375 10mM * 1mL in DMSO

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