Begacestat

• Target:

  Gamma-secretase|||Beta Amyloid

• Related Pathways:

  Proteases/Proteasome|||Stem Cells|||Neuroscience

• Bioactivity:

  Begacestat (GSI-953) is a potent and selective gamma-secretase inhibitor (?-secretase) that inhibits Amyloid-beta production with nanomolar potency, selectively inhibits cleavage of APP in cellular level Notch cleavage assays, reverses situational memory deficits, and can be used to study Alzheimer's disease.

• Smiles:

  C([C@H](NS(=O)(=O)C=1SC(Cl)=CC1)CO)(C(F)(F)F)C(F)(F)F

• Molecular Formula:

  C9H8ClF6NO3S2

• Molecular Weight:

  391.74

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  769169-27-9