AMD 3465

CAT: 0931-T14208-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T14208-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
185991-24-6
Target
HIV Protease|||CXCR
Related Pathways
Immunology/Inflammation|||Proteases/Proteasome|||Microbiology/Virology|||GPCR/G Protein|||Autophagy
Bioactivity
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM) . However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.
Smiles
N=1C=CC=CC1CNCC2=CC=C(C=C2)CN3CCNCCCNCCNCCC3
Molecular Formula
C24H38N6
Molecular Weight
410.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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