AMD 3465

• Target :

  HIV Protease|||CXCR

• Related Pathways :

  Immunology/Inflammation|||Proteases/Proteasome|||Microbiology/Virology|||GPCR/G Protein|||Autophagy

• Bioactivity :

  AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM) . However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.

• Smiles :

  N=1C=CC=CC1CNCC2=CC=C(C=C2)CN3CCNCCCNCCNCCC3

• Molecular Formula :

  C24H38N6

• Molecular Weight :

  410.6

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  185991-24-6