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Gemfibrozil

CAT: 0931-T1415-05Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0931-T1415-05Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
25812-30-0
Target
PPAR, Cytochromes P450, Adrenergic Receptor
Related Pathways
GPCR/G Protein, Metabolism, DNA Damage/DNA Repair, Neuroscience
Purity
0.999
Bioactivity
Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III) . The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C) . In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C) .
Smiles
CC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C1
Molecular Formula
C15H22O3
Molecular Weight
250.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Gemfibrozil

Gemfibrozil can cause cancer, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements.

CAS Number25812-30-0
PubChem CID3463
IUPAC Name5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
Molecular FormulaC15H22O3
Molecular Weight250.33
XLogP3.8
Topological Polar Surface Area46.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count18
Formal Charge0
Complexity273
SMILES
CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
InChI
InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChIKey
HEMJJKBWTPKOJG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Gemfibrozil
CAS: 25812-30-0
CID: 3463
Formula: C15H22O3
MW: 250.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight250.33
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass250.15689456
Monoisotopic Mass250.15689456
Topological Polar Surface Area46.5 Ų
Heavy Atom Count18
Formal Charge0
Complexity273
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FD23652-01Gemfibrozil
278313-01Iso-Gemfibrozil (gemfibrozil impurity)

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