AGN-195183

• Target:

  Autophagy|||Retinoid Receptor|||Others

• Related Pathways:

  Autophagy|||Others|||Metabolism

• Bioactivity:

  AGN 195183 is a potent and selective agonist of RAR? (Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RAR?/?. IC50 value: 3 nM (Kd) ; 200 nM (EC80, RAR Trans.) Target: RAR? agonist Compound 4 (AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation. Compound 4 (AGN 195183) is currently in Phase I/IIA clinical trials in cancer patients. Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3, however it does not cause the topical irritation induced by the RARa-selective retinoid, Am-580.

• Smiles:

  CC1(C)CCC(C)(C)c2c(Cl)c(O)c(cc12)C(=O)Nc1cc(F)c(C(O)=O)c(F)c1

• Molecular Formula:

  C22H22ClF2NO4

• Molecular Weight:

  437.86

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  367273-07-2