AGN-195183

CAT: 0931-MF-0031935-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0031935-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
367273-07-2
Target
Autophagy|||Retinoid Receptor|||Others
Related Pathways
Autophagy|||Others|||Metabolism
Bioactivity
AGN 195183 is a potent and selective agonist of RAR? (Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RAR?/?. IC50 value: 3 nM (Kd) ; 200 nM (EC80, RAR Trans.) Target: RAR? agonist Compound 4 (AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation. Compound 4 (AGN 195183) is currently in Phase I/IIA clinical trials in cancer patients. Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3, however it does not cause the topical irritation induced by the RARa-selective retinoid, Am-580.
Smiles
CC1(C)CCC(C)(C)c2c(Cl)c(O)c(cc12)C(=O)Nc1cc(F)c(C(O)=O)c(F)c1
Molecular Formula
C22H22ClF2NO4
Molecular Weight
437.86
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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BA3617-10AGN-195183
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A16293-100AGN 195183 100mg
A16293-10AGN 195183 10mg
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