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DMCL1-2

CAT: 0931-T13657Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T13657Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2351218-88-5
Target
Others, PROTACs, Apoptosis, Bcl-2 Family
Related Pathways
PROTAC, Apoptosis, Others
Bioactivity
DMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.
Smiles
O=C(O)C1=C(C=2C=CC=C(C=3C(=NN(C3COC4=CC=C(C=C4)N5CCN(CC5)S(=O)(=O)N(C)C)C)C)C2N1CCN6CCN(C(=O)COC7=CC=CC=8C(=O)N(C(=O)C78)C9C(=O)NC(=O)CC9)CC6)CCCOC%10=CC=CC=%11C=CC=CC%10%11
Molecular Formula
C61H66N10O12S
Molecular Weight
1163.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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