CDDO-dhTFEA

• Target:

  Apoptosis|||NF-?B|||Nrf2

• Related Pathways:

  Apoptosis|||NF-?B|||Immunology/Inflammation

• Purity:

  0.9959

• Bioactivity:

  CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-?B pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-?B and transforming growth factor-? pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD) .

• Smiles:

  [H][C@@]12CC (C) (C) CC[C@@]1 (CC[C@]1 (C) [C@]2 ([H]) C (=O) C[C@@]2 ([H]) [C@@]1 (C) CC[C@@]1 ([H]) C (C) (C) C (=O) C (=C[C@]21C) C#N) C (=O) NCC (F) (F) F

• Molecular Formula:

  C33H45F3N2O3

• Molecular Weight:

  574.72

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1191265-33-4