CDDO-dhTFEA

• CAS Number :

  1191265-33-4

• Target :

  Apoptosis|||NF-?B|||Nrf2

• Related Pathways :

  Apoptosis|||NF-?B|||Immunology/Inflammation

• Purity :

  0.9959

• Bioactivity :

  CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-?B pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-?B and transforming growth factor-? pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD) .

• Smiles :

  [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)NCC(F)(F)F

• Molecular Formula :

  C33H45F3N2O3

• Molecular Weight :

  574.72

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C