CDDO-dhTFEA

CAT: 0931-T13604-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T13604-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1191265-33-4
Target
Apoptosis|||NF-?B|||Nrf2
Related Pathways
Apoptosis|||NF-?B|||Immunology/Inflammation
Purity
0.9959
Bioactivity
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-?B pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-?B and transforming growth factor-? pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD) .
Smiles
[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)NCC(F)(F)F
Molecular Formula
C33H45F3N2O3
Molecular Weight
574.72
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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