2-Bromoacetamide

• Description :

  2-Bromoacetamide is a disinfection byproduct. 2-Bromoacetamide can inactivate liver alcohol dehydrogenase and interfere with microtubule and actin cytoskeletal function. 2-Bromoacetamide is a potent developmental toxicant in animals[1][2][3].

• UNSPSC :

  12352211

• Hazard Statement :

  H301, H314

• Target :

  Aldehyde Dehydrogenase (ALDH) ; Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/2-bromoacetamide.html

• Concentration :

  10mM

• Purity :

  99.93

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N)CBr

• Molecular Formula :

  C2H4BrNO

• Molecular Weight :

  137.96

• Precautions :

  H301, H314

• References & Citations :

  [1]Fries RW, et al. Activation of liver alcohol dehydrogenases by imidoesters generated in solution. Biochemistry. 1975;14 (23) :5233‐5238.|[2]Zhang C, et al. Developmental toxicity of 2-bromoacetamide on peri- and early post-implantation mouse embryos in vitro. Ecotoxicol Environ Saf. 2023 Mar 1;252:114612. |[3]Zhang C, et al. 2-bromoacetamide exposure impairs oocyte maturation in mice and humans primarily via disrupting the cytoskeleton. Ecotoxicol Environ Saf. 2024 Mar 1;272:116105.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [683-57-8]