2-Bromoacetamide

CAT: 0804-HY-W007330-01Size: 25 gDry Ice: NoHazardous: No
CAT#:0804-HY-W007330-01Size:25 g
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Description
2-Bromoacetamide is a disinfection byproduct. 2-Bromoacetamide can inactivate liver alcohol dehydrogenase and interfere with microtubule and actin cytoskeletal function. 2-Bromoacetamide is a potent developmental toxicant in animals[1][2][3].
CAS Number
[683-57-8]
UNSPSC
12352211
Hazard Statement
H301, H314
Target
Aldehyde Dehydrogenase (ALDH) ; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-bromoacetamide.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N)CBr
Molecular Formula
C2H4BrNO
Molecular Weight
137.96
Precautions
H301, H314
References & Citations
[1]Fries RW, et al. Activation of liver alcohol dehydrogenases by imidoesters generated in solution. Biochemistry. 1975;14 (23) :5233‐5238.|[2]Zhang C, et al. Developmental toxicity of 2-bromoacetamide on peri- and early post-implantation mouse embryos in vitro. Ecotoxicol Environ Saf. 2023 Mar 1;252:114612. |[3]Zhang C, et al. 2-bromoacetamide exposure impairs oocyte maturation in mice and humans primarily via disrupting the cytoskeleton. Ecotoxicol Environ Saf. 2024 Mar 1;272:116105.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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