Setmelanotide

Setmelanotide

• Target:

  Melanocortin Receptor

• Related Pathways:

  Neuroscience|||GPCR/G Protein

• Purity:

  0.9993

• Bioactivity:

  Setmelanotide (RM-493) is a selective melanocortin-4 receptor agonist with EC50 values of 0.27 and 0.28 nM for human and rat MC4R. Setmelanotide enhances cAMP signaling, demonstrates functional selectivity, activates sympathetic preganglionic neurons to influence blood pressure, and is widely used to probe MC4R-MRAP2 interactions. Setmelanotide contributes to obesity-related research by modulating hunger and satiety circuits, reversing risperidone-induced weight gain in mice, and helping characterize MC4R variants in pediatric metabolic disorders. The anti-inflammatory actions of Setmelanotide in astrocytoma cells and the utility in combination with calorie restriction further highlight its broad value in metabolic and neuroendocrine research.

• Smiles:

  C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H](C)NC(=O)[C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CSSC[C@@H](C(N)=O)NC3=O

• Molecular Formula:

  C49H68N18O9S2

• Molecular Weight:

  1117.31

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  920014-72-8