SB-657510

• Target:

  GPCR|||Neurotensin Receptor

• Related Pathways:

  GPCR/G Protein|||Endocrinology/Hormones

• Purity:

  0.9818

• Bioactivity:

  SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.

• Smiles:

  COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1

• Molecular Formula:

  C19H22BrClN2O5S

• Molecular Weight:

  505.81

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  474960-44-6