RU-SKI 43

• Target :

  Hedgehog/Smoothened|||Acyltransferase

• Related Pathways :

  GPCR/G Protein|||Metabolism|||Stem Cells

• Purity :

  0.9985

• Bioactivity :

  RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. It exhibits anticancer activity and is a potential treatment for lung adenocarcinomas. RU-SKI 43 reduces Gli-1 activation through smoothening-independent non-canonical signaling and inhibits Akt and mTOR pathway activity.

• Smiles :

  C(OC1=CC(C)=CC=C1)C2C3=C(CCN2C(CNCC(CC)C)=O)SC=C3

• Molecular Formula :

  C22H30N2O2S

• Molecular Weight :

  386.55

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1043797-53-0