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SBE13 (Hydrochloride)

CAT: 0804-HY-15158-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15158-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 Hydrochloride poorly inhibits Plk2 (IC50>66 μM) or Plk3 (IC50=875 nM) .
CAS Number
1052532-15-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SBE13-Hydrochloride.html
Purity
98.56
Solubility
DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic)
Smiles
COC1=CC=C(CCNCC2=CC=C(OCC3=CC=C(Cl)N=C3)C(OC)=C2)C=C1OC.[H]Cl
Molecular Formula
C24H28Cl2N2O4
Molecular Weight
479.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Keppner S, et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem. 2009 Nov;4 (11) :1806-9.|[2]Keppner S, et al. Fate of primary cells at the G?/S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle. 2011 Feb 15;10 (4) :708-20. Epub 2011 Feb 15.|[3]Keppner S, et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle. 2010 Feb 15;9 (4) :761-73. Epub 2010 Feb 16.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK1; PLK3

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