CLIC1 rabbit pAb

• Background:

  Chloride intracellular channel 1 (CLIC1) Homo sapiens Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

• Description:

  Chloride intracellular channel 1 (CLIC1) Homo sapiens Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane Chloride ion channel activity. [provided by RefSeq, Jul 2008],

• UniProt:

  O00299

• Swiss Prot:

  O00299

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthetic Peptide of CLIC1 AA range: 166-216

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IHC; IF

• Concentration:

  1 mg/ml

• Dilution:

  IHC 1:100-200

• Molecular Weight:

  30kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  30kD

• Fragment:

  IgG

• Subcellular Location:

  Nucleus . Nucleus membrane ; Single-pass membrane protein . Cytoplasm . Cell membrane ; Single-pass membrane protein . Mostly in the nucleus including in the nuclear membrane (PubMed:9139710, PubMed:12681486) . Small amount in the cytoplasm and the plasma membrane (PubMed:9139710) . Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11940526, PubMed:11551966, PubMed:14613939) . .

• Other Product Names:

  Chloride intracellular channel protein 1 (Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC)

• Gene ID (Human):

  1192