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PTC299

CAT: 0931-T12574-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T12574-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1256565-36-2
Target
DNA/RNA Synthesis, VEGFR, Dehydrogenase
Related Pathways
Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, DNA Damage/DNA Repair, Angiogenesis, Metabolism
Purity
0.9972
Bioactivity
PTC299 ((4-chlorophenyl) (1S) -6-chloro-1- (4-methoxyphenyl) -1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydrolactate dehydrogenase (DHODH) .
Smiles
COc1ccc(cc1)[C@@H]1N(CCc2c1[nH]c1ccc(Cl)cc21)C(=O)Oc1ccc(Cl)cc1
Molecular Formula
C25H20Cl2N2O3
Molecular Weight
467.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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