Ponatinib-d8

CAT: 0931-MF-0024617-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0024617-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1562993-37-6
Target
PDGFR|||VEGFR|||FGFR|||Autophagy|||Bcr-Abl|||Src
Related Pathways
Angiogenesis|||Autophagy|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling
Bioactivity
Ponatinib D8 is a deuterium labeled Ponatinib. Ponatinib is an orally active inhibitor of multi-targeted kinase (Abl, PDGFR?, VEGFR2, FGFR1, and Src with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM, respectively) .
Smiles
[2H]C1([2H])N(C)C([2H])([2H])C([2H])([2H])N(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)C1([2H])[2H]
Molecular Formula
C29H27F3N6O
Molecular Weight
540.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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