Ponatinib-d8

• Target:

  PDGFR|||VEGFR|||FGFR|||Autophagy|||Bcr-Abl|||Src

• Related Pathways:

  Angiogenesis|||Autophagy|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling

• Bioactivity:

  Ponatinib D8 is a deuterium labeled Ponatinib. Ponatinib is an orally active inhibitor of multi-targeted kinase (Abl, PDGFR?, VEGFR2, FGFR1, and Src with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM, respectively) .

• Smiles:

  [2H]C1 ([2H]) N (C) C ([2H]) ([2H]) C ([2H]) ([2H]) N (Cc2ccc (NC (=O) c3ccc (C) c (c3) C#Cc3cnc4cccnn34) cc2C (F) (F) F) C1 ([2H]) [2H]

• Molecular Formula:

  C29H27F3N6O

• Molecular Weight:

  540.61

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1562993-37-6