Ponatinib-d8

• Target :

  PDGFR|||VEGFR|||FGFR|||Autophagy|||Bcr-Abl|||Src

• Related Pathways :

  Angiogenesis|||Autophagy|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling

• Bioactivity :

  Ponatinib D8 is a deuterium labeled Ponatinib. Ponatinib is an orally active inhibitor of multi-targeted kinase (Abl, PDGFR?, VEGFR2, FGFR1, and Src with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM, respectively) .

• Smiles :

  [2H]C1([2H])N(C)C([2H])([2H])C([2H])([2H])N(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)C1([2H])[2H]

• Molecular Formula :

  C29H27F3N6O

• Molecular Weight :

  540.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1562993-37-6