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Ponatinib-d8

CAT: 0931-T12521-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T12521-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1562993-37-6
Target
PDGFR, VEGFR, FGFR, Autophagy, Bcr-Abl, Src
Related Pathways
Angiogenesis, Autophagy, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling
Bioactivity
Ponatinib D8 is a deuterium labeled Ponatinib. Ponatinib is an orally active inhibitor of multi-targeted kinase (Abl, PDGFRα, VEGFR2, FGFR1, and Src with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM, respectively) .
Smiles
[2H]C1([2H])N(C)C([2H])([2H])C([2H])([2H])N(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)C1([2H])[2H]
Molecular Formula
C29H27F3N6O
Molecular Weight
540.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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