Ponatinib

• Target:

  PDGFR|||c-Kit|||Autophagy|||FGFR|||VEGFR|||Bcr-Abl|||Src

• Related Pathways:

  Cytoskeletal Signaling|||Autophagy|||Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity:

  0.9974

• Bioactivity:

  Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor with IC50 values of 0.37 nM (Abl), 1.1 nM (PDGFR?), 1.5 nM (VEGFR2), 2.2 nM (FGFR1), and 5.4 nM (Src) .

• Smiles:

  C (#CC1=CC (C (NC2=CC (C (F) (F) F) =C (CN3CCN (C) CC3) C=C2) =O) =CC=C1C) C=4N5C (=NC4) C=CC=N5

• Molecular Formula:

  C29H27F3N6O

• Molecular Weight:

  532.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  943319-70-8