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PD 90780

CAT: 0931-T12384-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T12384-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
77422-99-2
Target
Others, Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors, Others
Purity
0.9922
Bioactivity
PD 90780 is a non-peptide antagonist of nerve growth factor (NGF) that interacts with NGF and prevents it from binding to p75NTR, inhibiting the NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
Smiles
Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O
Molecular Formula
C19H14N4O4
Molecular Weight
362.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

7-Benzamido-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic acid
CAS Number77422-99-2
PubChem CID9885305
IUPAC Name7-benzamido-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic acid
Molecular FormulaC19H14N4O4
Molecular Weight362.3
XLogP2.6
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity621
SMILES
CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3)C(=O)N4C1=CC(=N4)C(=O)O
InChI
InChI=1S/C19H14N4O4/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27/h2-10H,1H3,(H,20,24)(H,26,27)
InChIKey
IAZAGXDMMVWYKF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-Benzamido-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic acid
CAS: 77422-99-2
CID: 9885305
Formula: C19H14N4O4
MW: 362.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight362.3
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass362.10150494
Monoisotopic Mass362.10150494
Topological Polar Surface Area105 Ų
Heavy Atom Count27
Formal Charge0
Complexity621
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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