ML218

CAT: 0931-MF-0006499-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0006499-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1346233-68-8
Target
Calcium Channel
Related Pathways
Membrane transporter/Ion channel|||Metabolism
Purity
0.9945
Bioactivity
ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively) .ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN) .
Smiles
[H][C@@]12CN(CCC(C)(C)C)C[C@]1([H])[C@H]2CNC(=O)c1cc(Cl)cc(Cl)c1
Molecular Formula
C19H26Cl2N2O
Molecular Weight
369.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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