LV-320

• Target:

  Autophagy|||Cysteine Protease

• Related Pathways:

  Proteases/Proteasome|||Autophagy

• Bioactivity:

  LV-320 is a potent, uncompetitive ATG4B inhibitor with an IC50 of 24.5 ?M and a Kd of 16 ?M. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic, and active in vivo. These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts [1].

• Smiles:

  OC(=O)CCSC(SCCc1ccccc1)c1ccc(\C=C\c2ccnc3cc(Cl)ccc23)cc1

• Molecular Formula:

  C29H26ClNO2S2

• Molecular Weight:

  520.11

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2449093-46-1