Leu-AMS

CAT: 0931-T11840-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T11840-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
288591-93-5
Target
Antibacterial|||Others
Related Pathways
Microbiology/Virology|||Others
Bioactivity
Leu-AMS, a leucine analogue and potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, exhibits cytotoxic effects in both cancer and normal cells and hampers bacterial growth. It specifically inhibits LRS's catalytic activity without impacting the leucine-induced activation of mTORC1.
Smiles
CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Molecular Formula
C16H25N7O7S
Molecular Weight
459.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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