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JHU395

CAT: 0931-T11717-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T11717-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2079938-92-2
Target
Others, Apoptosis
Related Pathways
Others, Apoptosis
Purity
0.9975
Bioactivity
JHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON) . It demonstrates delivery of DON to malignant peripheral nerve sheath tumor (MPNST) both in vitro and in vivo, resulting in significant antitumor activity in MPNST. Additionally, JHU395 exhibits plasma stability.
Smiles
C(OC(C(C)(C)C)=O)(OC(N[C@H](C(OC(C)C)=O)CCC(C=[N+]=[N-])=O)=O)C1=CC=CC=C1
Molecular Formula
C22H29N3O7
Molecular Weight
447.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
S8892-25mgJHU395

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