Desonide

• Target :

  Glucocorticoid Receptor|||Huntingtin|||Apoptosis

• Related Pathways :

  Neuroscience|||Apoptosis|||Endocrinology/Hormones

• Purity :

  0.9974

• Bioactivity :

  Desonide (Prednacinolone) is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release of arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

• Smiles :

  [H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)CO

• Molecular Formula :

  C24H32O6

• Molecular Weight :

  416.51

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  638-94-8