ICA-105665

CAT: 0931-T11606-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T11606-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2694728-63-5

Target

Potassium Channel, Others

Related Pathways

Membrane transporter/Ion channel, Others

Bioactivity

ICA-105665 (PF-04895162) is a potent and orally active opener of neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels. ICA-105665 had low cytotoxic potential in human hepatocytes but inhibited liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 μM) . ICA-105665 can penetrate the central nervous system (CNS) and has antiseizure effects [1][2][3][4].

Smiles

N(C(CC1=CC=C(F)C=C1)=O)N2C(=NC=3C(C2=O)=CC=C(F)C3)C4CC4

Molecular Formula

C19H15F2N3O2

Molecular Weight

355.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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