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TCEP (hydrochloride)

CAT: 0804-HY-W011500-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W011500-01Size:100 mg
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Description
TCEP hydrochloride (Tris (2-carboxyethyl) phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry[1][2][3][4].
CAS Number
51805-45-9
Product Name Alternative
Tris (2-​carboxyethyl) ​phosphine hydrochloride
UNSPSC
12352211
Hazard Statement
H314
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tcep-hydrochloride.html
Purity
99.8
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic; adjust pH to 7 with NaOH)
Smiles
O=C(O)CCP(CCC(O)=O)CCC(O)=O.Cl
Molecular Formula
C9H16ClO6P
Molecular Weight
286.65
Precautions
H314
References & Citations
[1]Dieguez-Acuña FJ, et al. Inhibition of NF-kappaB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris (2-carboxyethyl) phosphine hydrochloride (TCEP), on detection of impaired NF-kappaB-DNA binding by thiol-directed agents. Toxicol In Vitro. 2000 Feb;14 (1) :7-16.|[2]Duchardt F, et al. A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency. J Biol Chem. 2009 Dec 25;284 (52) :36099-108.|[3]Sequeira MA, et al. Modulating amyloid fibrillation in a minimalist model peptide by intermolecular disulfide chemical reduction. Phys Chem Chem Phys. 2019 Jun 5;21 (22) :11916-11923.|[4]Wu R, et al. Effects of Small Molecules on DNA Adsorption by Gold Nanoparticles and a Case Study of Tris (2-carboxyethyl) phosphine (TCEP) . Langmuir. 2019 Oct 15;35 (41) :13461-13468.|[5]Han JC, Han GY. A procedure for quantitative determination of tris (2-carboxyethyl) phosphine, an odorless reducing agent more stable and effective than dithiothreitol. Anal Biochem. 1994;220 (1) :5-10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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