GNF4877

• CAS Number :

  2041073-22-5

• Target :

  DYRK|||GSK-3

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Stem Cells|||PI3K/Akt/mTOR signaling|||Cell Cycle/Checkpoint

• Purity :

  0.994

• Bioactivity :

  GNF4877 is a potent inhibitor of DYRK1A and GSK3? (IC50s: 6 nM and 16 nM, respectively), resulting in the blockade of nuclear export of nuclear factor of activated T-cells (NFATc) and increased ?-cell proliferation.

• Smiles :

  CC(C)Oc1ccc(F)c(c1)-c1cnc(N)c(n1)C(=O)Nc1cnccc1N1CCC[C@H](C1)C(O)=O

• Molecular Formula :

  C25H27FN6O4

• Molecular Weight :

  494.52

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C