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GNF4877

CAT: 0931-T11447-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T11447-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2041073-22-5
Target
DYRK, GSK-3
Related Pathways
Tyrosine Kinase/Adaptors, Stem Cells, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint
Purity
0.994
Bioactivity
GNF4877 is a potent inhibitor of DYRK1A and GSK3β (IC50s: 6 nM and 16 nM, respectively), resulting in the blockade of nuclear export of nuclear factor of activated T-cells (NFATc) and increased β-cell proliferation.
Smiles
CC(C)Oc1ccc(F)c(c1)-c1cnc(N)c(n1)C(=O)Nc1cnccc1N1CCC[C@H](C1)C(O)=O
Molecular Formula
C25H27FN6O4
Molecular Weight
494.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS133129GNF4877
bs-60294C-01GNF4877 --- β Cell Proliferation Inducer

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