Products for Research Use Only
RegisterLogin

E-7386

CAT: 0931-T11136-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T11136-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1799824-08-0
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Purity
0.9991
Bioactivity
E-7386 is an oral active CBP/ -catenin modulator.
Smiles
[H][C@]12CN(Cc3cccc(n3)N3CC(C3)N3CCN(CC)CC3)C(=O)[C@H](Cc3ccc(O)cc3F)N1C(=O)CN(CC=C)N2C(=O)NCc1ccccc1
Molecular Formula
C39H48FN9O4
Molecular Weight
725.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

E-7386

CBP/beta-catenin Modulator E7386 is an orally bioavailable, specific inhibitor of the canonical Wnt/beta-catenin signaling pathway, with potential antineoplastic activity. Upon oral administration, CBP/beta-catenin modulator E7386 inhibits beta-catenin and prevents the interaction of beta-catenin with its transcriptional coactivator, CREB (cAMP response element-binding) binding protein (CBP). This prevents binding of beta-catenin/CBP to WRE (Wnt-responsive element), and inhibits the activation of transcription of a wide range of target genes of Wnt/beta-catenin signaling, thereby preventing gene expression of many Wnt-related, pro-survival proteins and suppressing tumor cell growth. The Wnt/beta-catenin signaling pathway regulates cell morphology, motility, and proliferation; aberrant regulation of this pathway leads to neoplastic proliferation. Beta-catenin is frequently mutated in various tumors.

CAS Number1799824-08-0
PubChem CID91810345
IUPAC Name(6S,9aS)-N-benzyl-8-[[6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]-2-pyridinyl]methyl]-6-[(2-fluoro-4-hydroxyphenyl)methyl]-4,7-dioxo-2-prop-2-enyl-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazine-1-carboxamide
Molecular FormulaC39H48FN9O4
Molecular Weight725.9
XLogP3.4
Topological Polar Surface Area119
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Heavy Atom Count53
Formal Charge0
Complexity1280
SMILES
CCN1CCN(CC1)C2CN(C2)C3=CC=CC(=N3)CN4C[C@H]5N([C@H](C4=O)CC6=C(C=C(C=C6)O)F)C(=O)CN(N5C(=O)NCC7=CC=CC=C7)CC=C
InChI
InChI=1S/C39H48FN9O4/c1-3-15-47-27-37(51)48-34(20-29-13-14-32(50)21-33(29)40)38(52)46(26-36(48)49(47)39(53)41-22-28-9-6-5-7-10-28)23-30-11-8-12-35(42-30)45-24-31(25-45)44-18-16-43(4-2)17-19-44/h3,5-14,21,31,34,36,50H,1,4,15-20,22-27H2,2H3,(H,41,53)/t34-,36-/m0/s1
InChIKey
ZGNKNLOBYFTGRG-GIWKVKTRSA-N
Chemical Structure
2D Structure
2D structure of E-7386
CAS: 1799824-08-0
CID: 91810345
Formula: C39H48FN9O4
MW: 725.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight725.9
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Exact Mass725.38132921
Monoisotopic Mass725.38132921
Topological Polar Surface Area119 Ų
Heavy Atom Count53
Formal Charge0
Complexity1280
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T12578-01(E, E) -RAMB4
TN7254-01(E, E) -Farnesol
TN7995-01(E, E, E, ) -10,12,14-Hexadecatrienal
TXB-00590-01(E, E) -Farnesyl bromide
TYD-02153-01(E, E) -Piperonyl-CoA
TXB-00593-01Cathepsin E substrate e
T36410-019 (E),11 (E),13 (E) -Octadecatrienoic Acid
TYD-00956-01(E, E) -2,4-Hexadienal
TN7954-01(E, E) -10,12-Hexadecadienal
TN7966-01(E, E) -10,12-Hexadecadienol

Alternative Products

CatalogName
TRC-E102405-25MGE-7386
FE167967-01E 7386
A17089-50E-7386 50mg
A17089-10E-7386 10mg
A17089-5E-7386 5mg
A17089-100E-7386 100mg
A17089-1E-7386 1mg
A17089-25E-7386 25mg

Popular Products