Destruxin B

• Target :

  Bcl-2 Family|||Caspase|||Others|||Apoptosis

• Related Pathways :

  Proteases/Proteasome|||Others|||Apoptosis

• Bioactivity :

  Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochondrial pathway. Destruxin B through caspase-mediated apoptosis can significantly activate caspase-3 in vitro and in vivo, reducing the proliferation of tumor cells.

• Smiles :

  CC[C@H](C)[C@]1(C)NC(=O)[C@]2(C)CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O

• Molecular Formula :

  C30H51N5O7

• Molecular Weight :

  593.766

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2503-26-6