Destruxin B

• Target:

  Bcl-2 Family|||Caspase|||Others|||Apoptosis

• Related Pathways:

  Proteases/Proteasome|||Others|||Apoptosis

• Bioactivity:

  Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochondrial pathway. Destruxin B through caspase-mediated apoptosis can significantly activate caspase-3 in vitro and in vivo, reducing the proliferation of tumor cells.

• Smiles:

  CC[C@H] (C) [C@]1 (C) NC (=O) [C@]2 (C) CCCN2C (=O) [C@@H] (CC (C) C) OC (=O) CCNC (=O) [C@H] (C) N (C) C (=O) [C@H] (C (C) C) N (C) C1=O

• Molecular Formula:

  C30H51N5O7

• Molecular Weight:

  593.766

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2503-26-6