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Destruxin B

CAT: 0931-T11009-01Size: 1 mgDry Ice: NoHazardous: No
T11009-011 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2503-26-6
Target
Bcl-2 Family|||Caspase|||Others|||Apoptosis
Related Pathways
Proteases/Proteasome|||Others|||Apoptosis
Bioactivity
Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochondrial pathway. Destruxin B through caspase-mediated apoptosis can significantly activate caspase-3 in vitro and in vivo, reducing the proliferation of tumor cells.
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CC[C@H](C)[C@]1(C)NC(=O)[C@]2(C)CCCN2C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O
Molecular Formula
C30H51N5O7
Molecular Weight
593.766
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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