Samuraciclib hydrochloride

• Target:

  Apoptosis|||CDK

• Related Pathways:

  Cell Cycle/Checkpoint|||Apoptosis

• Purity:

  0.998

• Bioactivity:

  Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold higher than CDK1, CDK2 (IC50 is 578 nM), CDK5 and CDK9 respectively. Samuraciclib hydrochloride inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 ?M. Samuraciclib hydrochloride has anti-tumor effects.

• Smiles:

  Cl.CC (C) c1cnn2c (NCc3ccccc3) cc (NC[C@H]3CCNC[C@@H]3O) nc12

• Molecular Formula:

  C22H31ClN6O

• Molecular Weight:

  430.97

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1805789-54-1